Do polynucleotides work if you already have wrinkles?
By Dr Anand Raman · Published · Updated · 2 min read

As we age, wrinkles and fine lines become more prominent, leading many to seek effective treatments for skin rejuvenation. Polynucleotides have emerged as a promising option in the realm of aesthetic medicine, known for their regenerative properties. This article explores whether polynucleotides are effective in treating existing wrinkles, with a focus on their application.
Effectiveness on Existing Wrinkles
Immediate Impact
While polynucleotide treatments do not provide instant results, you may notice some immediate effects due to the hydration and plumping of the skin. These immediate changes are often subtle and primarily due to the physical presence of the injected solution rather than the biological activity of the polynucleotides.
Short-term Improvements
In the days following the treatment, you might experience mild redness, swelling, or bruising at the injection sites. These effects are temporary and typically subside within a few hours to a couple of days. During this period, initial improvements in skin texture and hydration may become more noticeable.
Long-term Benefits
Polynucleotide treatments are designed to work gradually by stimulating the skin’s natural regenerative processes. Significant improvements in the appearance of wrinkles and fine lines typically become noticeable within a few weeks. As the polynucleotides promote collagen and elastin production, the skin becomes firmer and more elastic, leading to a reduction in the depth and severity of wrinkles.
Comparing Polynucleotides to Other Treatments
Polynucleotides offer a unique approach to wrinkle treatment compared to other options such as Botox or dermal fillers. While Botox temporarily relaxes facial muscles to smooth out wrinkles, and fillers provide immediate volume to plump the skin, polynucleotides work by enhancing the skin’s natural regenerative capabilities. This means that while the results may take longer to become fully apparent, they are also more natural and sustainable in the long term.
Suitability for Different Skin Types
Polynucleotide treatments are suitable for various skin types and conditions. They are particularly effective for individuals with mature skin showing signs of aging, such as wrinkles, fine lines, and loss of elasticity. The regenerative properties of polynucleotides make them a versatile treatment option for those seeking comprehensive skin rejuvenation.
Choosing the Right Clinic
When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience.
Conclusion
Polynucleotides are effective in treating existing wrinkles by promoting collagen and elastin production, improving hydration, and supporting the skin’s natural repair processes. While the results are not instant, the gradual and natural improvements make polynucleotide treatments an excellent choice for long-term skin rejuvenation. If you are based in Clapham or South London and are interested in exploring polynucleotide treatments, our clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.
Contact us today at our Dr Raman Medical Aesthetics clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.
Feel free to book Botox treatments at our clinic in Balham with Dr. Raman on our booking page.
Our clinic has another article about the length of polynucleotides treatments.
Frequently asked questions
Do polynucleotides work if you already have wrinkles?
Yes. Polynucleotides can treat existing wrinkles by promoting collagen and elastin production, improving hydration and supporting the skin's natural repair. As the skin becomes firmer and more elastic, wrinkles can become less deep. The results are gradual, not instant.
How long do polynucleotides take to work on wrinkles?
Significant improvement in wrinkles and fine lines typically shows within a few weeks. Polynucleotides work gradually by stimulating the skin's natural regeneration. You may see a subtle effect straight away, but this is mainly from the injected fluid hydrating and plumping the skin.
How are polynucleotides different from Botox and fillers for wrinkles?
Botox temporarily relaxes facial muscles, and fillers give immediate volume. Polynucleotides instead improve the skin's own ability to regenerate. Their results take longer to appear fully, but they are more natural and longer lasting.
What are the side effects of polynucleotide injections?
In the days after treatment, you might have mild redness, swelling or bruising where the injections were given. These effects are temporary and usually settle within a few hours to a couple of days. Your practitioner should explain the possible side effects and aftercare before treatment.


