Polynucleotides: behind the hype
By Dr Anand Raman · Published · Updated · 3 min read

Polynucleotides have garnered significant attention in the world of aesthetic medicine, praised for their regenerative properties and effectiveness in skin rejuvenation. As with any popular treatment, it’s essential to look beyond the hype and understand the science, benefits, and realistic expectations associated with polynucleotides.
The Science Behind Polynucleotides
Molecular Structure and Function
Polynucleotides consist of repeated units of nucleotides, each composed of three parts: a nitrogenous base, a sugar molecule, and a phosphate group. These nucleotides link together to form long chains, which can be incorporated into treatments to support cellular functions and promote tissue repair.
Mechanism of Action
Polynucleotides work by providing a structural framework that supports cellular regeneration. They attract water molecules, improving skin hydration and providing a plumping effect. Additionally, polynucleotides stimulate collagen and elastin production, essential proteins for maintaining skin firmness and elasticity. This multi-faceted approach helps to address various signs of aging, including wrinkles and fine lines.
Benefits of Polynucleotide Treatments
Skin Rejuvenation
One of the primary benefits of polynucleotide treatments is their ability to rejuvenate the skin. By enhancing the skin’s natural repair processes, these treatments can improve overall skin texture, tone, and elasticity. This makes polynucleotides particularly beneficial for individuals looking to reduce signs of aging and achieve a more youthful appearance.
Long-Lasting Results
Polynucleotide treatments are known for their long-lasting effects. While the initial improvements may become noticeable within a few weeks, the full benefits typically manifest after two to three months. The results can be maintained for six to twelve months, depending on individual factors and the specific area treated.
Minimally Invasive
Unlike surgical procedures, polynucleotide treatments are minimally invasive. They involve a series of injections, making them a convenient option for individuals with busy lifestyles. The treatment has minimal downtime, allowing patients to resume their daily activities shortly after the procedure.
Why the Hype?
Effective and Natural-Looking Results
The hype around polynucleotides is largely due to their effectiveness in delivering natural-looking results. Unlike treatments that provide immediate but temporary effects, polynucleotides work gradually to improve the skin’s condition from within. This leads to more subtle and natural enhancements, which are highly valued by patients.
Versatility
Polynucleotides are versatile and can be used to treat various skin concerns, from wrinkles and fine lines to scars and overall skin rejuvenation. This versatility makes them an attractive option for a wide range of patients seeking different aesthetic improvements.
Managing Expectations
While polynucleotides offer numerous benefits, it’s essential to manage expectations. Results vary from person to person, and factors such as age, skin type, and lifestyle can influence the outcome. During a consultation, your practitioner will discuss realistic expectations and develop a treatment plan tailored to your specific needs.
Choosing the Right Clinic
When considering polynucleotide treatments, it is essential to choose a reputable clinic with experienced practitioners. A thorough consultation should be conducted to assess your skin condition and discuss your aesthetic goals. The practitioner should provide detailed information about the treatment process, potential side effects, and aftercare instructions to ensure a safe and satisfying experience. Our Clapham clinic offers expert guidance and personalized care to help you achieve your aesthetic goals safely and effectively.
Contact us today at our Dr Raman Medical Aesthetics clinic in Balham for a personalised consultation. We’re more than just a Botox clinic—we’re your partners in your aesthetic journey in Clapham.
Feel free to book Botox treatments at our clinic in Balham with Dr. Raman on our booking page.
Our clinic has another article about why polynucleotides may not be suitable for vegans.
Frequently asked questions
Do polynucleotides really work?
Polynucleotides can improve skin texture, tone and elasticity by supporting the skin's natural repair processes. They work gradually from within, which gives subtle, natural-looking results. However, results vary from person to person. Age, skin type and lifestyle can all affect the outcome, so discuss realistic expectations with your practitioner.
How long do polynucleotide results last?
Results can be maintained for six to twelve months, depending on individual factors and the area treated. The first improvements may show within a few weeks. The full benefits typically appear after two to three months.
How do polynucleotides work?
Polynucleotides are long chains of nucleotides that give the skin a framework to support cell regeneration. They attract water, which hydrates the skin and gives a plumping effect. They also stimulate collagen and elastin, the proteins that keep skin firm and elastic. Together, these effects help address wrinkles and fine lines.
Is there downtime after polynucleotides?
Downtime is minimal. Polynucleotide treatment is minimally invasive and involves a series of injections rather than surgery. Most patients can return to their daily activities shortly after the procedure. Your practitioner should give you information about potential side effects and aftercare.


